During the 5th edition of SpliTech, “International Conference on Smart and Sustainable Technologies”, within the track “IoT Security”, the paper “A Rapid Prototyping Approach in Industry4.0 based on Secure Hardware and Azure Sphere Cloud ” has been presented. It has been written by Luca Cremona and Nicola Carrus of Rold, in collaboration with researchers from the University of Salento and with the support of Microsoft Italy. The paper presents an innovative application case in which IoT devices, characterized by high security protocols in data collection, enable the monitoring of production processes in the scenario of Industry 4.0.